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Biogenesis of secretory granules Implications arising from the immature secretory granule in the regulated pathway of secretion
Author(s) -
Tooze Sharon A.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80805-d
Subject(s) - granule (geology) , secretory protein , secretion , secretory pathway , microbiology and biotechnology , secretory vesicle , golgi apparatus , biogenesis , biology , exocytosis , chemistry , biochemistry , endoplasmic reticulum , gene , paleontology
In endocrine cells the regulated secretion of hormones, peptides, enzymes and neurotransmitters into the external medium occurs when mature secretory granules fuse with the plasma membrane. Secretory granules form at the trans‐Golgi network (TGN) by envelopment of the dense‐core aggregate of regulated secretory proteins by a specific membrane. The secretory granules initially formed at the TGN, referred to here as immature secretory granules, are morphologically and biochemically distinct from mature secretory granules. The functional similarities and differences between the immature secretory granule and the mature secretory granule, and the events involved in the maturation of the secretory granules are briefly discussed.