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The control of interferon‐inducible gene expression
Author(s) -
Kerr Ian M.,
Stark George R.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80802-a
Subject(s) - gene , gene expression , interferon , genetics , biology , microbiology and biotechnology , chemistry , computational biology
The αβ interferons (IFNs) transiently induce genes through an IFN‐stimulable DNA response element (ISRE). IFN‐cell surface receptor interaction triggers the cytoplasmic activation of the complex primary transcription factor E, which on translocation and interaction with the ISRE initiates transcription. Whether E is activated directly through the receptor(s) or through a more classical second message pathway(s) and the roles of additional factors in the αβ and γ IFN responses remain to be established. Meanwhile analysis of mutants has revealed complexity and overlap in the α,β and γ IFN response pathways and the products of at least two viruses have been shown to inhibit IFN‐inducible gene expression.