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Down‐regulation of a kinase defective PKC‐α
Author(s) -
Pears Cathy,
Parker Peter J.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80776-y
Subject(s) - autophosphorylation , protein kinase c , microbiology and biotechnology , kinase , mutant , chemistry , protein kinase a , phosphorylation , cyclin dependent kinase 9 , map kinase kinase kinase , mitogen activated protein kinase kinase , biology , biochemistry , gene
A kinase defective mutant of PKC‐α down‐regulates in response to phorboI esters as effectively as the wild‐type protein when introduced into COS‐1 cells. This demonstrates that intramolecular autophosphorylation is not a prerequisite for down‐regulation.