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Activation of Epstein‐Barr virus promoters by a growth‐factor and a glucocorticoid
Author(s) -
Schuster C.,
Chasserot-Golaz S.,
Beck G.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80767-w
Subject(s) - glucocorticoid , promoter , epstein–barr virus , virology , virus , chemistry , biology , genetics , gene , immunology , gene expression
Transforming growth factor‐β (TGF‐β) and a glucocorticosteroid, Dexamethasone (DXM), both cause transcriptional induction of Epstein‐Barr virus (EBV) early antigens (EA) in Daudi lymphoma cells. The viral induction occurs through the viral promoter DR overlapping an origin of replication which is active during the lytic cycle. Each hormone requires specific regions on the DR promoter. Since these regions also mediate the action of two viral transcription factors, EBI and R, it may be emphasized that EBI and/or R are involved in the EA induction process by TGF‐β and by DXM.