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Inhibition of protein kinase C arrests proliferation of human tumors
Author(s) -
Miñana Maria-Dolores,
Felipo Vicente,
Cortés Francisco,
Grisolía Santiago
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80761-q
Subject(s) - cell growth , protein kinase c , protein kinase a , kinase , cell culture , biology , microbiology and biotechnology , cyclin dependent kinase 2 , human brain , growth inhibition , cancer research , biochemistry , neuroscience , genetics
We have shown that inhibition of protein kinase C by 1‐5‐isoquinolinylsulfonyl‐2‐methylpiperazine, H7, induces differentiation and inhibits proliferation of Neuro 2a cells. We have now tested if H7 is able to inhibit proliferation of: 1) human tumor cell lines from tissues other than brain; and 2) primary cultured cells from several human brain tumors. H7 inhibits, in a dose‐dependent manner, proliferation of all human tumor cell lines tested and of primary cultured cells from human brain tumors. These results indicate that inhibition of protein kinase C inhibits proliferation of tumoral cells, therefore, H7, and likely other inhibitors of protein kinase C, could be useful in the clinical treatment of brain (and probably other) tumors.