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Selective effect of inhibitors on inner mitochondrial membrane channels
Author(s) -
Antonenko Yuri N.,
Kinnally Kathleen W.,
Perini Sean,
Tedeschi Henry
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80731-h
Subject(s) - inner mitochondrial membrane , translocase of the inner membrane , chemistry , biophysics , membrane potential , mitochondrion , mitochondrial apoptosis induced channel , microbiology and biotechnology , mitochondrial membrane transport protein , biochemistry , biology
The effect of amphiphilic cationic drugs on the channel activity of the mitochondrial inner membrane was examined with patch‐clamp techniques. The therapeutic drugs amiodarone, propranolol and quinine reduced the probability of being open for the multiconductance channel (MCC) activity (levels from 30 pS to over I nS). While amiodarone decreased the probability of being open for the voltage dependent ∼ 100 pS channel, it increased the conductance 42 ± 20% (mean ± SD, n = 6) with no significant change in mean open time. Similar results were obtained with propranolol. These data indicate that the ∼ 100 pS channel is distinct from MCC activity.