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Ubiquitin—protein conjugates and αB crystallin are selectively present in cells undergoing major cytomorphological reorganisation in early chicken embryos
Author(s) -
Scotting Paul,
McDermott Helen,
Mayer R.John
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80728-l
Subject(s) - myotome , notochord , ubiquitin , microbiology and biotechnology , embryo , crystallin , biology , cytoplasm , embryogenesis , somite , biochemistry , gene
Ubiquitin—protein conjugates and αB crystallin are detected immunohistochemically in cells undergoing extensive morphological reorganisation in early chicken embryos. Cytoplasmic ubiquitinated proteins and αB crystallin are coordinately found in cells of the lens, notochord and myotome. The antigens appear in the myotome cells precisely, at the point at which the cells begin to migrate from the dorsomedial lip of the dermamyotome. The findings indicate that ubiquitin and αB crystallin may have a coordinate role in the extensive architectural remodeling which occurs in these developing tissues in the early chick embryo, Some form of functional association between protein ubiquitination and αB crystallin in cells may explain why αB crystallin is found with ubiquitin—protein deposits in some neurodegenerative diseases.