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The induction of adipose conversion in 3T3‐L1 cells is associated with early phosphorylation of a 60‐kDa nuclear protein
Author(s) -
Brandes Ruth,
Arad Rivka,
Bar-Tana Jacob
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80725-i
Subject(s) - phosphorylation , adipose tissue , 3t3 l1 , chemistry , microbiology and biotechnology , 3t3 cells , nuclear protein , protein phosphorylation , biochemistry , biology , protein kinase a , adipocyte , gene , transfection , transcription factor
The induction of adipose conversion in 3T3‐L1 cells by bezafibrate has been shown to be enhanced by dibutyryl‐cAMP. We here report that the induction of adipose conversion in 3T3‐L1 cells, by either bezafibrate and dibutyryl cAMP, or isobutylmethyxanthine alone, is associated with a very early phosphorylation of a 60‐kDa acidic protein found in the nuclear fraction.