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Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E
Author(s) -
Forsmark Patrik,
Åberg Fredrik,
Norling Birgitta,
Nordenbrand Kerstin,
Dallner Gustav,
Ernster Lars
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80720-n
Subject(s) - submitochondrial particle , ubiquinol , chemistry , lipid peroxidation , vitamin e , biochemistry , vitamin , mitochondrion , antioxidant , cytochrome c , coenzyme q – cytochrome c reductase
The relationship between the antioxidant effects of reduced coenzyme Q 10 (ubiquinol, UQH 2 ) and vitamin E (α‐tocopherol) was investigated in beef heart submitochondrial particles in which lipid peroxidation was initiated by incubation with ascorbate + ADP‐Fe 3+ . These effects were examined after extraction of coenzyme Q 10 (UQ‐10) and vitamin E from the particles and reincorporation of the same components alone or in combination. The results show that UQHZ efficiently inhibits lipid peroxidation even when vitamin E is absent. It is concluded that UQH 2 can inhibit lipid peroxidation directly, without the mediation of vitamin E.