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Interaction between the left‐handed Z‐DNA and polyamine The crystal structure of the d(CG) 3 and N ‐(2‐aminoethyl)‐1,4‐diamino‐butane complex
Author(s) -
Ohishi Hirofumi,
Kunisawa Shoko,
van der Marel Gijs,
van Boom Jacques H.,
Rich Alexander,
Wang Andrew H.-J.,
Tomita Ken-ichi,
Hakoshima Toshio
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80694-x
Subject(s) - polyamine , crystallography , dna , chemistry , molecule , duplex (building) , z dna , stereochemistry , butane , crystal structure , magnesium , crystal (programming language) , phosphate , sodium , resolution (logic) , biochemistry , organic chemistry , catalysis , artificial intelligence , computer science , programming language
The DNA fragment d(CG) 3 was co‐crystallized with N ‐(2‐aminoethyl)‐1,4‐diaminobutane (PA(24)), a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG) 3 , and well diffracted the X‐ray intensities up to 1.0 Å resolution. The d(CG) 3 took a left‐handed Z‐DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG) 3 duplex.