Premium
Evidence for a role of phosphofructokinase and tRNA in the polyribosome disaggregation of amino acid deficiency
Author(s) -
Rabinovitz Marco
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80605-3
Subject(s) - phosphofructokinase , polysome , transfer rna , biochemistry , amino acid , chemistry , glycolysis , ribosome , enzyme , rna , gene
The activity of rabbit muscle phosphofructokinase was inhibited by transfer ribonucleic acid. This inhibition was reduced by inclusion of an amino‐acyl‐tRNA charging system. The results are discussed in terms of the loss of ATP in amino acid deprived cells and in the critical role of fructose 1,6‐diphosphate in peptide chain initiation.