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Multiple control level governing H1 o mRNA and protein accumulation
Author(s) -
Khochbin Saadi,
Gorka Claude,
Lawrence Jean-Jacques
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80554-g
Subject(s) - chemistry , messenger rna , biochemistry , gene
We have studied the variation of histone H1 o and its coding mRNA during rat liver regeneration after partial hepatectomy. Our data showed that while H1 o decreased when cell proliferation was initiated, H1 o mRNA accumulated in a proliferantion‐dependent manner as did H3 mRNA. These results showed two interesting aspects of the regulation of H1 o expression in vivo, confirming results we have obtained previously in vitro: first H1 o mRNA accumulation is a proliferation‐dependent event; second, H1 o protein accumulation may be uncoupled from that of its coding mRNA.