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Kinetic and cross‐linking studies indicate different receptors for endothelins and sarafotoxins in the ileum and cerebellum
Author(s) -
Galron Ronit,
Bdolah Avner,
Kochva Elazar,
Wollberg Zvi,
Kloog Yoel,
Sokolovsky Mordechai
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80542-b
Subject(s) - cerebellum , endothelins , receptor , chemistry , biochemistry , neuroscience , biophysics , biology , endothelin receptor
Kinetics of ligand/receptor interactions using ET‐1, ET‐3 and SRTX‐b were studied and cross‐linking experiments carried out in guinea pig ileum and rat cerebellar preparations. Dissociation studies indicate that the two regions are characterized by different receptor subtypes and different modes of ligand binding. Autoradiographic patterns obtained following cross‐linking of ET‐1 and ET‐3 to the different issues support these conclusions.