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Absence of insulinotropic glucagon‐like peptide‐I(7–37) receptors on isolated rat liver hepatocytes
Author(s) -
Blackmore Peter F.,
Mojsov Svetlana,
Exton John H.,
Habener Joel F.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80541-a
Subject(s) - glucagon , endocrinology , medicine , glucagon like peptide 1 , islet , chemistry , secretagogue , glucagon like peptide 1 receptor , gluconeogenesis , receptor , agonist , glucagon receptor , antagonist , insulin , biology , type 2 diabetes , diabetes mellitus , metabolism
The effects of glucagon and the glucagon‐like peptide GLP‐I(7–37) were compared in rat liver hepatocytes. Glucagon elevated cAMP, elevated intracellular free calcium ([Ca 2+ ] 1 ), activated phosphorylase and stimulated gluconeogenesis, whereas GLP‐I(7–37) was without effect on any of these parameters. GLP‐I(7–37) did not block any of the actions of glucagon. The glucagon analog, des His 1 [Glu 9 ] glucagon, amide, was a partial agonist in liver, but also was an effective antagonist of glucagon actions in liver but not those of GLP‐I(7–37) in islet B cells. It was concluded that in the rat, GLP‐I(7–37) is a potent insulin secretagogue [1] but is without effect on liver.