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Generation of interleukin‐8 by plasmin from AVLPR‐interleukin‐8, the human fibroblast‐derived neutrophil chemotactic factor
Author(s) -
Nakagawa Hideo,
Hatakeyama Shinji,
Ikesue Atsutoshi,
Miyai Hisato
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80526-9
Subject(s) - chemotaxis , plasmin , interleukin , interleukin 8 , interleukin 1β , chemistry , immunology , microbiology and biotechnology , cytokine , biology , biochemistry , receptor , enzyme
Plasmin mainly cleaved the Arg 5 ‐Ser 6 bond of Arg‐Val‐Leu‐Pro‐Arg‐interleukin‐8 (AVLPR‐IL‐8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR‐IL‐8 to IL‐8 and the inactive pentapeptide, though a minor cleavage of AVLPR‐IL‐8 by plasmin at Lys 8 ‐Glu 9 bond occurred.