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Isolation of high‐molecular‐weight C‐type natriuretic peptide from the heart of a cartilaginous fish (European dogfish, Scyliorhinus canicula )
Author(s) -
Suzuki Reiko,
Takahashi Akiyoshi,
Hazon Neil,
Takei Yoshio
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80505-w
Subject(s) - scyliorhinus canicula , natriuretic peptide , peptide , protein primary structure , medicine , peptide sequence , homology (biology) , biology , fish <actinopterygii> , endocrinology , amino acid , chemistry , biochemistry , microbiology and biotechnology , gene , fishery , heart failure
A high‐molecular‐weight form of C‐type natriuretic peptide (CNP) was isolated from both cardiac atria and ventrieles of European dogfish, Scyliorhinus canicula , and its primary structure was determined. The peptide consists of 115 amino acid residues, in which the C‐terminal 22 residues show high homology to CNPs identified to date. This is the first direct evidence for the presence of natriuretic peptide in the cartilaginous fish, and for the presence of CNP in an organ other than the brain.