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A novel natriuretic peptide isolated from eel cardiac ventricles
Author(s) -
Takei Toshio,
Takahashi Akiyoshi,
Watanabe Takushi X.,
Nakajima Kiichiro,
Sakakibara Shumpei
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80504-v
Subject(s) - cardiac ventricle , medicine , atrial natriuretic peptide , natriuretic peptide , chemistry , npr1 , peptide , cardiology , biochemistry , heart failure , ventricle
A new natriuretic peptide, which exhibits the entire spectrum of actions known to be characteristics of atrial and brain natriuretic peptides (ANP and BNP), was isolated from eel cardiac ventricles and has been named ventricular natriuretic peptide (VNP). The primary structure of eel VNP is characterized by its uniquely long C‐ terminal ‘tall’ that extends from the second half‐cystine. Thus, eel VNP appears to be a novel natriuretic peptide of a type not found in mammals. With respect to natriuretic (rat) and vasodepressor (rat and eel) activities, eel VNP is much more potent than human ANP in eels and almost equipotent in rats. Strong tachyphylaxis is observed for the vasodepressor effect in both rats and eels, whereas it is not observed for the natriuretic effect in rats.