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The transcriptional control proteins c‐Myb and v‐Myb contain a basic region DNA binding motif
Author(s) -
Carr Mark D.,
Mott Richard F.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80498-r
Subject(s) - myb , leucine zipper , bzip domain , biology , helix turn helix , dna , genetics , dna binding site , dna binding protein , binding site , transcription factor , homology (biology) , sequence motif , transcription (linguistics) , dna binding domain , amino acid , promoter , gene , gene expression , linguistics , philosophy
A class of transcriptional control proteins, typified by c‐Myb, are characterised by a highly conserved N‐terminal DNA binding domain, which is composed of either 2 or 3 imperfect repeats of about 52 amino acids. A sequence homology search of the SWISSPROT protein sequence data bank with this region from mouse c‐Myb has allowed us to identify an area near the C‐terminus of repeat 2 that contains a short sequence motif, known as the basic region, which forms the DNA binding site in both leucine zipper and helix‐loop‐helix transcription factors. We therefore propose that this region of repeat 2 and the homologous part of repeat 3 will form the Myb DNA binding site.