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Protein kinase C(19–31) pseudosubstrate inhibition of insulin action in rat adipocytes
Author(s) -
Standaert Mary L.,
Sasse Joachim,
Cooper Denise R.,
Farese Robert V.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80463-d
Subject(s) - medicine , endocrinology , insulin , protein kinase a , adipocyte , chemistry , action (physics) , adipose tissue , biology , kinase , biochemistry , physics , quantum mechanics
Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC(19–31) inhibited insulin‐stimulated hexose uptake and lipogenesis, with no effect on basal values. The effect was dose‐dependent with respective IC 10 values of 30 μM and 600 μM for insulin‐stimulated hexose uptake in electroporated and intact adipocytes. These studies indicate that PKC may play a role in the mediation of insulin action in adipocytes.