Premium
Alpha 2‐macroglobulin synthesis in interleukin‐6‐stimulated human neuronal (SH‐SY5Y neuroblastoma) cells Potential significance for the processing of Alzheimer β‐amyloid precursor protein
Author(s) -
Ganter Ursula,
Strauss Sylvia,
Jonas Uwe,
Weidemann Andreas,
Beyreuther Konrad,
Volk Benedikt,
Berger Mathias,
Bauer Joachim
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80460-k
Subject(s) - amyloid precursor protein , alpha 2 macroglobulin , secretion , macroglobulin , sh sy5y , stimulation , alzheimer's disease , p3 peptide , biology , amyloid precursor protein secretase , endocrinology , central nervous system , microbiology and biotechnology , chemistry , neuroblastoma , medicine , cell culture , disease , genetics
Cultured human neuronal (SH‐SY5Y neuroblastoma) cells synthesize and secrete the potent protease inhibitor alpha 2‐macroglobulin (a2M) upon stimulation with interleukin‐6(IL‐6) indicating that alpha 2‐macroglobulin behaves as an acute‐phase protein in the human central nervous system. Exogenous addition of a2M to the cultured neuronal cells resulted in only a slight inhibition of Alzheimer βA4‐amyloid precursor protein (APP) synthesis, but markedly inhibited its secretion pointing to the possibility that a2M may affect the proteolytic APP processing. Evidence is provided that IL‐6 and a2M are involved in Alzheimer's disease pathogenesis.