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Structural symmetry of the extracellular domain of the Cytokine/Growth hormone/Prolactin receptor family and Interferon receptors revealed by Hydrophobic Cluster Analysis
Author(s) -
Thoreau E.,
Petridou B.,
Kelly P.A.,
Djiane J.,
Mor J.P.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80437-8
Subject(s) - prolactin receptor , receptor , cytokine receptor , prolactin , extracellular , cytokine , amino acid , biology , immunoglobulin domain , antibody , chemistry , biochemistry , microbiology and biotechnology , hormone , genetics
Sequence comparison based on Hydrophobic Cluster Analysis procedures shows that the extracellular ≈ 200 amino acids domains of cytokines receptors belonging to the Cytokine/Growth hormone/Prolactin receptor family and to the Interferon one are organized in two homologous subdomains. Further, comparison of the subdomains of 32 independent sequences and of a lot of already recognized homologous domains with data bases could lead to the hypothesis that these ≈ 100 amino acids subdomains could possess the overall fold of the constant immunoglobulin domains and so could belong to the immunoglobulin superfamily.