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Ethanol has an acute effect on bile acid biosynthesis in man
Author(s) -
Axelson Magnus,
Mörk Birgitta,
Sjövall Jan
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80382-d
Subject(s) - biosynthesis , chemistry , ethanol , biochemistry , gene
A single dose of ethanol, 0.4 g/kg body weight, was found to give a 5–15 fold increase of the plasma concentrations of 7α‐hydroxy‐cholesterol and 7α‐hydroxy‐4‐cholesten‐3‐one in humans. The rise was maximal 4 h after ethanol ingestion, was dose‐dependent and was not seen in a cholecystectomized subject. The effect was selective for these and some other 7α‐hydroxylated C 27 ‐intermediates in bile acid bioxynthesis. The changes are compatible with an acute stimulation of cholesterol 7α‐hydroxylase possibly due to an ethanol‐induced inhibition of gallbladder contraction resulting in an interruption of the enterohepatic circulation of bile acids. The effect is of interest in relation to the influence of ethanol consumption on cardiovascular and gallstone diseases.