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Molecular structure of the Japanese hepatitis C viral genome
Author(s) -
Kato Nobuyuki,
Hijikata Makoto,
Nakagawa Mosanori,
Ootsuyama Yuko,
Muraiso Kanae,
Ohkoshi Showgo,
Shimotohno Kunitada
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80322-t
Subject(s) - virology , hepatitis c virus , ns3 , rna , biology , homology (biology) , nucleic acid sequence , genome , rna polymerase , virus , polymerase , nucleotide , peptide sequence , rna dependent rna polymerase , genetics , microbiology and biotechnology , amino acid , gene
The amino acid sequence of the polyprotein deduced from the nucleotide sequence of the Japanese hepatitis C virus genome (N. Kato et. al. (1990) Proc. Natl. Acad. Sci. USA 87, 9524–9528)indicated that this virus is a member of a new class of positive‐stranded RNA viruses. Several domains of this polyprotein also showed weak homology with those of flaviviruses and pestiviruses including the chymotrypsin‐like serine proteinase. NTPase and RNA‐dependent RNA polymerase