Premium
Biphasic expression of slow myosin light chains and slow tropomyosin isoforms during the development of the human quadriceps muscle
Author(s) -
Laurent-Winter C.,
Soussi-Yanicostas N.,
Butler-Browne G.S.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80315-t
Subject(s) - tropomyosin , gene isoform , myosin , myosin light chain kinase , immunoglobulin light chain , chemistry , biology , microbiology and biotechnology , biochemistry , antibody , immunology , gene
Using a two‐dimensional electrophoresis technique coupled with sensitive silver staining, we have investigated the chronology of appearance of the myosin light chain and tropomyosin isoforms during early stages of human quadriceps development. Our results show that slow myosin light chains and the slow tropomyosin isoform are not detected at 6 weeks of gestation. These isoforms transiently appear between 12.5 weeks and 15 weeks of gestation and then disappear. The slow myosin light chains are re‐expressed at 31 weeks of gestation and the slow tropomyosin isoform later at 36 weeks of gestation, and normally remained expressed into the adulthood. Our study thus reveals a biphasic expression of the slow myosin light chains and the slow tropomyosin isoform in developing human quadriceps muscle.