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Eukaryotic DNA primase abortive synthesis of oligoadenylates
Author(s) -
Podust V.N.,
Vladimirova O.V.,
Manakova E.N.,
Lavrik O.I.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80312-q
Subject(s) - primase , trimer , dna polymerase , oligonucleotide , dna , polymerase , human placenta , dna clamp , biochemistry , microbiology and biotechnology , dna polymerase ii , biology , chemistry , dimer , polymerase chain reaction , reverse transcriptase , placenta , gene , genetics , pregnancy , fetus , organic chemistry
Calf thymus DNA polymerase α‐primase, human placenta DNA polymerase α‐primase and human placenta DNA primase synthesized oligoriboadenylates of a preferred length of 2–10 nucleotides and multimeric oligoribonucleotides of a modal length of about 10 monomers on a poly(dT) template. The dimer and trimer were the prevalent products of the polymerization reaction. However, only the oligonucleotides from heptamers to decamers were elongated efficiently by DNA polymerase α.