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The organization of the gene for the human cerebroside sulfate activator protein
Author(s) -
Holtschmidt Hans,
Sandhoff Konrad,
Fürst Werner,
Kwon Hae Young,
Schnabel Doris,
Suzuki Kunihiko
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80308-p
Subject(s) - exon , intron , activator (genetics) , complementary dna , rna splicing , cerebroside , gene , microbiology and biotechnology , tandem exon duplication , exon trapping , alternative splicing , genomic dna , biology , genetics , biochemistry , rna
The organization of 14 exons covering 97% of the cDNA sequence of human cerebroside sulfate activator protein precursor has been determined from two overlapping EMBL‐4 human genomic clones extending over 17kb. All exons and exon/intron splice junctions and five introns were sequenced. Exon 8 consists of only 9 bp and is involved in alternative splicing which generates three different mRNAs of cerebroside sulfate activator precursor.