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The oxygenation of cholesterol esters by the reticulocyte lipoxygenase
Author(s) -
Belkner Jutta,
Wiesner Rainer,
Kühn Hartmut,
Lankin Vadim Z.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80263-3
Subject(s) - chemistry , lipoxygenase , cholesterol , oxygenation , chromatography , gas chromatography , biochemistry , polyunsaturated fatty acid , reticulocyte , fatty acid , enzyme , biology , ecology , messenger rna , gene
The arachidonate 15‐lipoxygenase from rabbit reticulocytes oxygenates cholesterol esters containing polyenoic fatty acids. Cholesterol esterified with saturated fatty acids is not oxygenated. The structures of the oxygenation products formed from various cholesterol esters have been identified by high pressure liquid chromatography, UV‐spectroscopy and gas chromatography/mass spectroscopy. Oxygenated cholesterol esters have been detected in atherosclerotic plaques of human aortas.