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Immunological studies of the toxic site in ammodytoxin A
Author(s) -
Čurin-Šerbec Vladka,
Novak Djurdja,
Babnik Joža,
Turk Dušan,
Gubenšek Franc
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80231-q
Subject(s) - chemistry , biology
Two monoclonal antibodies against the native ammodytoxin A and four site‐directed polyclonal antibodies against synthetic peptides derived from the primary structure of the toxin were prepared in order to estimate the localization of its toxic site. Some of the antibodies neutralized the lethal toxicity of the toxin, thus indicating an approximate position of the toxic or receptor binding site on the molecule that is different from those predicted by comparison with a number of known sequences.