Premium
Antibodies against the cytoplasmic tail can differentiate between the quaternary forms of the M r 46000 mannose 6‐phosphate receptor
Author(s) -
Nadimpalli Siva Kumar,
Schmidt Bernhard,
von Figura Kurt,
Hille Annette
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80204-g
Subject(s) - cytoplasm , receptor , antiserum , protein quaternary structure , mannose , antibody , chemistry , mannose 6 phosphate , biochemistry , microbiology and biotechnology , biology , gene , genetics , growth factor , protein subunit
An antiserum against a peptide of the cytoplasmic tail of the M r 46000 mannose 6‐phosphate receptor is described which recognizes preferentially the tetrameric versus the dimeric form of this receptor. This indicates that the conformation of the cytoplasmic tail, which harbours signals necessary for the trafficking of the receptor, depends on the quaternary structure of the receptor.