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Transcriptional activity of the phosphoenolpyruvate carboxykinase gene decreases in regenerating rat liver
Author(s) -
Milland Julie,
Schreiber Gerhard
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80144-r
Subject(s) - phosphoenolpyruvate carboxykinase , gene , chemistry , biochemistry , biology
Rat cytosolic phosphoenolpyruvate carboxykinase (PEPCK) gene expression and enzyme activity in liver were studied in rats fasted for 12 hours before and after partial hepatectomy, sham operation or no operation. Transcriptional activity and mRNA levels decreased in regenerating liver compared to sham‐operated and unoperated controls. In contrast, PEPCK enzyme activity in regenerating liver was similar to that in livers of sham‐operated and unoperated controls. Since all the animals were fasted the decrease in transcription is probably caused by some factor other than insulin, the known repressor of PEPCK gene expression.