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Differential expression of the mouse D 2 dopamine receptor isoforms
Author(s) -
Montmayeur J.P.,
Bausero P.,
Amlaiky N.,
Maroteaux L.,
Hen R.,
Borrelli E.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80125-m
Subject(s) - receptor , gene isoform , dopamine receptor , spiperone , alternative splicing , microbiology and biotechnology , dopamine , chemistry , transfection , biology , gene , biochemistry , endocrinology
We have identified and characterized the cDNAs corresponding to the mouse D 2 dopamine receptors. We show that in the mouse the D 2 dopamine receptor is found in two forms, generated by alternative splicing of the same gene, mRNA distribution analysis of areas expressing the D 2 receptors shows that the larger form is the most abundant, except in the brain stem where the shorter form is predominant. Membranes of mammalian cells translently transfected with both forms of D 2 receptor bind [ 1 H]spiperone with a high affinity.