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Cloning and functional expression of a TEA‐sensitive A‐type potassium channel from rat brain
Author(s) -
Schro̊ter Klaus-Hasso,
Ruppersberg Johann Peter,
Wunder Frank,
Rettig Jens,
Stocker Martin,
Pongs Olaf
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80119-n
Subject(s) - cloning (programming) , potassium channel , chemistry , potassium , molecular cloning , microbiology and biotechnology , biochemistry , biology , biophysics , gene expression , gene , computer science , programming language , organic chemistry
A rat brain cDNA (Raw3) related to the Drosophila Show K* channel family has been characterized, Raw3 cRNA leads to the formation of TEA‐insensitive, fast inactivating (A‐type) K* channels when injected into Xenopus leavis oocytes. Raw3 channels have markedly different properties from the previously cloned rat A‐type K* channel RCK4, Raw3 channels operate in the positive voltage range.