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Porcine pancreas extract decreases blood‐ionized calcium in mice and inhibits osteoclast formation and bone resorption in culture
Author(s) -
Yoneda Toshiyuki,
Takaoka Yoshito,
Alsina Maria M.,
Garcia Joyce,
Mundy Gregory R.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80109-g
Subject(s) - endocrinology , medicine , calcium metabolism , pancreas , bone resorption , calcium , prostaglandin e2 , osteoclast , chemistry , tartrate resistant acid phosphatase , parathyroid hormone , pancreatitis , receptor
Patients with acute pancreatitis commonly manifest hypocalcemia for reasons which are unknown. We found that porcine pancreas extracts (PX) significantly decreased blood‐ionized calcium in Balb/e mice. Partially‐purified PX with a molecular mass of approximately 27 kDa decreased blood‐ionized calcium in the mice. Partially‐purified PX suppressed not only 41 Ca release from fetal rat long bones which had been stimulated by parathyroid hormone, interleukin‐1 α, tumor necrosis factor, transforming growth factor‐α, 1.25‐dihydroxyvitamin D 3 and prostaglandin E 2 , but tartrate‐resistant acid phosphatase‐positive multinucleated cell formation in the presence of 1,25‐dihydroxyvitamin D 3 in mouse marrow cultures. The results suggest that there is an as yet‐unidentified bone metabolism‐regulating substance in porcine pancreas which might be responsible for the hypocalcemia associated with acute pancreatitis.