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Solution structure of μ‐conotoxin GIIIA analysed by 2D‐NMR and distance geometry calculations
Author(s) -
Ott Karl Heinz,
Becker Stefan,
Gordon Robert D.,
Rüterjans Heinz
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80107-e
Subject(s) - folding (dsp implementation) , geometry , conotoxin , chemistry , crystallography , spectral line , nmr spectra database , physics , peptide , nuclear magnetic resonance , mathematics , engineering , structural engineering , astronomy
We have investigated the structure of μ‐conotoxin GIIIA by 2D‐NMR methods. The assignment of 1 H NMR spectra and a quantitative analysis of NOE and J‐coupling data are presented. These results were used for the calculation of secondary structure elements of μ‐conotoxin GIIIA. Distance geometry calculations were carried out to define the global folding of the peptide.