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The role of lipid peroxidation products in cumene hydroperoxide‐induced Ca 2+ efflux from mitochondria
Author(s) -
Gogvadze V.G.,
Zhukova A.A.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80034-z
Subject(s) - cumene hydroperoxide , lipid peroxidation , chemistry , mitochondrion , efflux , cumene , biochemistry , biophysics , oxidative stress , biology , catalysis
Cumene hydroperoxide‐induced calcium release from mitochondria has been studied. Activation of lipid peroxidation by increasing concentrations of cumene hydroperoxide does not enhance calcium efflux induced by low (up to 50 μM) concentration of cumene hydroperoxide. It is concluded that cumene hydroperoxide‐induced calcium release depends mainly on processes coupled to hydroperoxide reduction by an endogenous enzyme system.