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Changes in mitochondrial and microsomal rat liver coenzyme Q 9 , and Q 10 content induced by dietary fat and endogenous lipid peroxidation
Author(s) -
Huertas J.R.,
Battino M.,
Lenaz G.,
Mataix F.J.
Publication year - 1991
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(91)80022-u
Subject(s) - lipid peroxidation , microsome , chemistry , endogeny , biochemistry , endocrinology , coenzyme a , mitochondrion , medicine , biology , enzyme , reductase
The influence of different kinds of dietary fat (8%) and of endogenous lipid peroxidation with regard to coenzyme Q 9 (CoQ 9 ) and coenzyme Q 10 (CoQ 10 ) concentrations in mitochondria and microsomes from rat liver has been investigated by means of an HPLC technique. Although the different diet fats used did not produce any effect on microsomes, it was possible to show that each experimental diet differently influenced the mitochondrial levels of CoQ 9 and CoQ 10 . The highest mitochondrial CoQ content was found in case of a diet supplemented with corn oil. An endogenous oxidative stress induced by adriamycin was able to produce a sharp decrease in mitochondrial CoQ 9 levels in the rats to which corn oil was administered. The results suggest that dietary fat ought to be considered when studies concerning CoQ mitochondrial levels are carried out.