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Cholesterol oxidation on fluorocarbon emulsion surface leads to the formation of 7‐peroxycholesterol
Author(s) -
Beriozov Alan T.,
Ivanov Aleksey S.,
Ivkov Vladimir G.,
Obraztsov Victor V.,
Khalilov Elvis M.,
Archakov Alexander I.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81509-m
Subject(s) - fluorocarbon , emulsion , chemistry , chemical engineering , organic chemistry , engineering
Formation of biologically active oxidized derivatives of cholesterol as a result of its oxidation on the surface of fluorocarbon emulsions was studied. A single product of cholesterol oxidation, 7‐peroxycholesterol, was found. It was shown that 7‐peroxycholesterol and its derivative 7‐keto‐cholesterol inhibit the rosette formation between human T‐lymphocytes and sheep erythrocytes. These substances exert a strong cytostatic action on the growth of procaryotic and eucaryotic cell cultures. Thus, oxidative modification of blood plasma components on the surface of fluorocarbon emulsion particles with the formation of highly active compounds must be taken into account when using the fluorocarbon emulsions in medicine.