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Stable rightward shifts of the oxyhemoglobin dissocation curve induced by encapsulation of inositol hexaphosphate in red blood cells using electroporation
Author(s) -
Mouneimne Youssef,
Barhoumi Roula,
Myers Tim,
Slogoff Stephen,
Nicolau Claude
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81453-u
Subject(s) - electroporation , chemistry , inositol , biophysics , biochemistry , biology , receptor , gene
Rightward shifts of 50–100% of the P 50 values in the oxygen dissociation curve of intracellular hemoglobin are obtained after encapsulation of inositol hexaphosphate in mouse and dog red blood cells (RBC) by electroporation. Life spans of mouse RBC‐myo‐inositol hexaphosphate in circulation are unchanged from the normal RBC values.