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An inhibitor of protein synthesis initiation from Alhagi kirgisorum S
Author(s) -
Smailov Salim K.,
Mukhamedzhanov Bektas G.,
Lee Anatoly V.,
Iskakov Bulat K.,
Denisenko Oleg N.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81448-w
Subject(s) - reticulocyte , protein biosynthesis , chemistry , translation (biology) , aminoacylation , wheat germ , ternary complex , eukaryotic translation , biochemistry , gtp' , stereochemistry , transfer rna , messenger rna , rna , enzyme , gene
Polyproanthocyanidin ‐ a plant phenolic compound from Alhagi kirgisorum S. effectively inhibited protein synthesis in rabbit reticulocyte and wheat germ cell‐free systems. Poly‐proanthocyanidin inhibited translation only at the level of initiation and not at the clongation level and aminoacylation of tRNA. The inhibitory effect of the phenolic compound is due to the blockage of the ternary complex formation of cIF‐2 with GTP and initiator Met‐tRNA.