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Active transport of proteins into the nucleus
Author(s) -
Wagner Philipp,
Kunz Jeannette,
Koller Antonius,
Hall Michael N.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81425-n
Subject(s) - nuclear pore , nuclear transport , nucleus , microbiology and biotechnology , biophysics , inner membrane , chemistry , nucleoporin , nuclear protein , cell nucleus , envelope (radar) , transport protein , chromosomal translocation , biology , biochemistry , transcription factor , gene , telecommunications , radar , computer science , mitochondrion
Nuclear proteins are actively and posttranslationally transported across the nuclear envelope. This transport is highly selective process that can be divided into two steps, receptor‐binding followed by translocation through the nuclear envelope. Receptor‐binding is mediated by nuclear localization signals that have been identified in many nuclear proteins. Translocation is energy‐dependent and occurs through the nuclear pore complex.