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Chromosomal reallocation of the chicken c‐myb locus and organization of 3′‐proximal coding exons
Author(s) -
Soret Johann,
Vellard Michel,
Viegas-Pequignot Evani,
Apiou Françoise,
Dutrillaux Bernard,
Perbal Bernard
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81387-4
Subject(s) - exon , myb , biology , genetics , locus (genetics) , gene , coding region , genomic organization , genomic dna , centromere , in situ hybridization , microbiology and biotechnology , chromosome , genome , gene expression
In the course of our studies concerning the tissue‐specific expression of the c‐myb proto‐oncogene, we have established the nucleotide sequence of the chicken c‐myb 3′‐proximal coding exons. In situ hybridization performed with different genomic DNA probes corresponding to nearly all the c‐myb gene allowed us to localize the corresponding locus on the large acrocentric chromosome 3 in chicken. Our sequencing data also indicate that the 3′‐proximal noncoding sequences represented in c‐myb mRNA species are derived from non‐contiguous exons.