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Hormonal regulation of LH receptor mRNA and expression in the rat ovary
Author(s) -
Zhang-Zhi Hu,
ChonHwa TsaiMorris,
Ellen Buczko,
Maria L. Dufau
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81359-v
Subject(s) - medicine , endocrinology , follicular phase , receptor , ovulation , luteinizing hormone , ovary , biology , luteal phase , agonist , homologous desensitization , stimulation , desensitization (medicine) , hormone receptor , hormone , cancer , breast cancer
Agonist‐induced changes in expression and mRNA levels of luteinizing hormone (LH) receptors were compared during stimulation of ovarian follicular maturation and luteinization by gonadotropic hormones. Three major species of LH receptor mRNA, 5.8, 2.6 and 2.3 kb, were present throughout differentiation and changed similarly, the 5.8 kb species being consistently more abundant than the smaller forms. The increased expression of plasma‐membrane LH receptors in preovulatory follicles and luteinized ovaries and their homologous down‐regulation during follicular and luteal desensitization were closely correlated with the steady‐state receptor mRNA levels. The reappearance of LH receptors following desensitization during the luteal stage was preceded by an increase in mRNA levels. These studies have demonstrated that the expression of LH receptors during follicular maturation, ovulation and desensitization is related to the prevailing levels of receptor mRNA in the ovary.