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Effect of a high Na + diet on cell volume and Na + ‐stimulated ATPase activities of rat kidney membranes
Author(s) -
Vincenzo Campo,
Laura Henríquez,
Teresa Proverbio,
Reinaldo Marı́n,
Fulgencio Proverbio
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81338-o
Subject(s) - membrane , kidney , chemistry , atpase , radiochemistry , enzyme , biochemistry , biology , endocrinology
Proximal tubular cells from kidneys of male rats chronically fed with an isotonic NaCl solution, show a volume increase which is dependent on the length of the treatment with NaCl, when compared with control rats. Parallel to the cell volume increase, there is an increase of the ouabaininsensitive Na‐ATPase activity, whereas the ouabain‐sensitive Na.K‐ATPase activity remains unchanged. These results establish a clear relationship between a chronic Na‐diet, kidney cell volume and Na‐ATPase activity.