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Antibiotics ‐ cloning of biosynthetic pathways
Author(s) -
Kleinkauf Horst,
von Döhren Hans
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81294-x
Subject(s) - tripeptide , enzyme , cloning (programming) , antibiotics , biosynthesis , biochemistry , metabolic pathway , biology , sequence (biology) , chemistry , stereochemistry , peptide , computer science , programming language
Biosynthetic pathways leading to antibiotics have often been found to be clustered, and new organizational forms of multifunctional enzymes have been discovered. Such polyenzymes accomplish the synthesis of complex metabolites such as peptides or polyketides by a sequence of enzymatic reactions. So, reactions leading to the tripeptide precursor of β‐lactam antibiotics. ACV, or to the cycloundecapeptide cyclosporine have been fused into single polypeptide chain synthetases, respectively. In certain isofunctional sites restricted similarities have been detected.