Premium
Receptor‐mediated calcium entry
Author(s) -
Rink Timothy J.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81290-5
Subject(s) - calcium , cytosol , biophysics , receptor , depolarization , chemistry , microbiology and biotechnology , calcium in biology , intracellular , coupling (piping) , voltage dependent calcium channel , biochemistry , biology , materials science , organic chemistry , metallurgy , enzyme
Occupation of membrane receptors can evoke calcium signals by causing depolarisation and activating voltage‐operated calcium channels, by triggering internal release, or by stimulating calcium influx processes not gated by membrane potential, receptor‐mediated calcium entry, RCME. This brief review considers different possible coupling mechanisms and the proposal that entry can occur from external medium to intracellular store, by‐passing the cytosol, and regulated by the state of filling of the store. Recent studies using Mn 2+ as a probe for RCME are outlined, as are some new electrophysiologic measurements with human platelets and investigations of a novel blocker of RMCE, SK&F 96365.