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Eukaryotic DNA helicases
Author(s) -
Thömmes Pia,
Hübscher Ulrich
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81279-w
Subject(s) - helicase , computational biology , dna , biology , microbiology and biotechnology , chemistry , genetics , gene , rna
DNA is very stable in its double‐stranded form. For many processes of DNA metabolism, such as replication, repair, recombination and transcription, the DNA has to be brought transiently into a single‐stranded form. DNA helicases are enzymes capable of melting the hydrogen bonds of base pairs by using the energy of nucleoside‐5'‐triphosphate hydrolysis. This minireview focusses on the current knowledge of DNA helicases from eukaryotic cells.