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Amino acid sequence elucidation of human acrosin‐trypsin inhibitor (HUSI‐II) reveals that Kazal‐type proteinase inhibitors are structurally related to β‐subunits of glycoprotein hormones
Author(s) -
Fink Edwin,
Hehlein-Fink Christa,
Eulitz Manfred
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81273-q
Subject(s) - glycoprotein , acrosin , biochemistry , trypsin , peptide sequence , trypsin inhibitor , chemistry , amino acid , amino acid residue , sequence (biology) , glycopeptide , biology , enzyme , genetics , gene , semen , acrosome , antibiotics
The amino acid sequence of the acrosin‐trypsin inhibitor HUSI‐II from human seminal plasma is presented which unequivocally identifies HUSI‐II as being of Kazal‐type. In addition, the HUSI‐II sequence shows a striking similarity to the middle part of glycoprotein hormone β‐subunits thus revealing a hitherto unknown structural and evolutionary relationship between Kazal‐type inhibitors and glycoprotein hormones.