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N‐ myc suppression and cell cycle arrest at G 1 phase by prostaglandins
Author(s) -
Marui Nobuyuki,
Sakai Toshiyuki,
Hosokawa Nobuko,
Yoshida Mitsunori,
Aoike Akira,
Kawai Keiichi,
Nishino Hoyoku,
Fukushima Masanori
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81224-c
Subject(s) - cell cycle checkpoint , prostaglandin , prostaglandin e , cell cycle , prostaglandin f , chemistry , prostaglandin d2 , medicine , cell , cancer research , microbiology and biotechnology , endocrinology , biology , biochemistry
Effects of cyclopentenone prostaglandins, Δ 12 ‐prostaglandin (PG) J 2 and PGA 2 on the expression of N‐ myc in relation to the effects on cell cycle progression were investigated using human neuroblastoma cell line GOTO. Both PGs suppressed M‐ myc expression within several hours prior to inducing G 1 arrest. The N‐ myc suppression with Δ 12 ‐PGJ 2 was continued but with PGA 2 it was gradually released, followed by the release of G 1 arrest. These results suggest that Δ 12 ‐PGJ 2 and PGA 2 inhibit cell cycle progression in strong association with N‐ myc suppression and Δ 12 ‐PGJ 2 is more potent and has a longer effect than PGA 2 .