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Interleukin‐1 stimulates glucose transport in rat adipose cells
Author(s) -
Garcia-Welsh Adrienne,
Schneiderman Joanna S.,
Baly Deborah L.
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81207-5
Subject(s) - glucose transporter , adipose tissue , beta (programming language) , endocrinology , medicine , chemistry , stimulation , glucose uptake , kinetics , insulin , biophysics , biology , physics , quantum mechanics , computer science , programming language
The effect of interleukin 1 (IL‐1) on glucose transport activity in isolated rat adipose cells was examined. IL‐1β stimulated 3‐ O ‐methylglucose (3 O MG) transport in a time and dose dependent manner. This effect appears to be due to increased maximal transport velocity ( V max of the carrier. Addition of insulin and IL‐1β resulted in an additive stimulation of transport, suggesting different mechanisms. IL‐1α had no effect on glucose transport. Glu‐4, a relatively inactive IL‐1β analogue in most cells, stimulated glucose uptake in a time and dose dependent manner with kinetics indistinguishable from those of IL‐ 1β.