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Calcium ion activation of the anion‐conducting channel in the rat liver mitochondrial inner membrane
Author(s) -
Selwyn Michael J.,
Ng Catherine L.T.,
Choo Hui Lim
Publication year - 1990
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(90)81155-h
Subject(s) - calcium , inner mitochondrial membrane , chemistry , biophysics , ion channel , ion , inner membrane , membrane potential , membrane , voltage dependent anion channel , mitochondrion , calcium channel , biochemistry , biology , bacterial outer membrane , escherichia coli , gene , receptor , organic chemistry
Stimulation of the rat liver mitochondrial inner‐membrane anion‐conducting channel by aeration is dependent on the concentration of Ca 2+ ions in the assay medium. Ca 2+ activates anion conduction in both aerated and non‐energised mitochondria but acts over a wider concentration range and produces a greater increase in anion‐conductivity in aerated mitochondria. EGTA reverses Ca 2+ stimulation but takes several seconds to act, indicating slow release of Ca 2+ from the activation site possibly on the matrix side of the inner mitochondrial membrane. It is suggested that this channel may respond to hormone‐induced changes in cytosolic Ca 2+ concentration.